Clinical Laboratory Improvement Amendments (CLIA): Application/Certification and Fee Payment

Select a link to learn more:

Application/certification

• How to Apply for a CLIA Certificate - Learn from Centers for Medicare & Medicaid Services (CMS) about the CLIA application process.
  • CLIA Application for Certification Form (CMS-116) (PDF)
  • Laboratory Quick Start Guide to CMS CLIA Certification (PDF)
  • CLIA Brochure: How to Obtain a CLIA Certificate (PDF)
  • CLIA Brochure: How to Obtain a CLIA Certificate of Waiver (PDF)
• CLIA Lab Changes Notification Summary (PDF) - A guide for when and how to provide notification about CLIA laboratory changes.

Fee payment

Pay CLIA Fees Online - Use the U.S. Department of the Treasury secure site to make fee payments from a bank account (ACH), debit or credit card.

• Guide for Paying CLIA Fees Online (PDF)
• CLIA Fee Schedule (PDF)