Skip to main content
State of Wisconsin flag

Official website of the State of Wisconsin

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock () or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

We have refreshed our website: Tell us what you think

Use the "Site Feedback" link found at the bottom of every webpage. We look forward to hearing from you!

COVID-19: Vaccine Guidance for People Who Are Moderately or Severely Immunocompromised

If you are moderately to severely immunocompromised (have a weakened immune system), you are at increased risk of severe COVID-19 illness and death. Your immune response to COVID-19 vaccination may not be as strong as in people who are not immunocompromised. As with vaccines for other diseases, you are protected best when you stay up to date with your COVID-19 vaccines. That means you should get all the COVID-19 vaccine doses recommended for you, when eligible.

Who is moderately or severely immunocompromised?

Many conditions and treatments can cause a person to be immunocompromised (having a weakened immune system). People are considered to be moderately to severely immunocompromised if they have:

  • Been receiving active cancer treatment for tumors or cancers of the blood.
  • Received an organ transplant and are taking medicine to suppress the immune system.
  • Received a stem cell transplant within the last two years or are taking medicine to suppress the immune system.
  • Moderate or severe primary immunodeficiency (such as DiGeorge syndrome, Wiskott-Aldrich syndrome).
  • Advanced or untreated HIV infection.
  • Active treatment with high-dose corticosteroids or other drugs that may suppress their immune response

Talk to your healthcare provider about COVID-19 vaccination and your medical condition. If you don't have a health care provider, call 211 or text COVID to 211-211 for some resources. Language assistance is available.

You can self-attest to your moderately or severely immunocompromised status. This means that you do not need any documentation of your status in order to receive COVID-19 vaccine doses wherever they are offered.

Staying up to date with COVID-19 vaccines while moderately or severely immunocompromised

You are up to date with your COVID-19 vaccines when you have completed a primary series and, when eligible, received the most recent booster dose recommended for you. The recommendations will be different depending on your health status, your age, and which vaccine you received.

You can use the Center's for Disease Control and Prevention's (CDC) COVID-19 booster tool to learn if and when you can get boosters to stay up to date with your COVID-19 vaccines.

If you are not moderately or severely immunocompromised, see the vaccine guidance for most people.

Children ages 6 months–11 years

Note: Pfizer-BioNTech and Moderna COVID-19 vaccines use different age groups for their children’s vaccines.

Children 6 months–4 years old
First Dose

Primary Series (original, monovalent Pfizer vaccine)

 

Second Dose

Primary Series (original, monovalent Pfizer vaccine)

Three weeks after your first dose

Third Dose

Primary Series (updated, bivalent Pfizer vaccine)

At least eight weeks after your second dose

 

Up to date: two weeks after the last dose in your primary series (your third dose), since a booster is not currently recommended for children in this age group

Children 5–11 years old
First Dose

Primary Series

 

Second Dose

Primary Series

Three weeks after your first dose

Third Dose

Primary Series

At least eight weeks after your second dose

Fourth Dose

Updated Booster

At least two months after your third dose

 

Up to date: immediately after you have received the most recent booster dose recommended for you

Note: Pfizer-BioNTech and Moderna COVID-19 vaccines use different age groups for their children’s vaccines.

Children 6 months–5 years old
First Dose

Primary Series

 

Second Dose

Primary Series

Four weeks after your first dose

Third Dose

Primary Series

At least four weeks after your second dose

Fourth Dose

Updated Moderna Booster

At least two months after your third dose

 

Up to date: immediately after you have received the most recent booster dose recommended for you

Children 6–11 years old
First Dose

Primary Series

 

Second Dose

Primary Series

Four weeks after your first dose

Third Dose

Primary Series

At least four weeks after your second dose

Fourth Dose

Updated Booster

At least two months after your third dose

 

Up to date: immediately after you have received the most recent booster dose recommended for you

Children and teens ages 12-17 years

First Dose

Primary Series

 

Second Dose

Primary Series

Three weeks after your first dose

Third Dose

Primary Series

At least four weeks after your second dose

Fourth Dose

Updated Pfizer or Moderna Booster

At least two months after your third dose or last booster

 

Up to date: immediately after you have received the most recent booster dose recommended for you

First Dose

Primary Series

 

Second Dose

Primary Series

Four weeks after your first dose

Third Dose

Primary Series

At least four weeks after your second dose

Fourth Dose

Updated Pfizer or Moderna Booster

At least two months after your third dose or last booster

 

Up to date: immediately after you have received the most recent booster dose recommended for you

First Dose

Primary Series

 

Second Dose

Primary Series

Three weeks after your first dose

Third Dose

Updated Pfizer or Moderna Booster

At least two months after your second dose

 

Up to date: immediately after you have received the most recent booster dose recommended for you

Adults ages 18 years or older

First Dose

Primary Series

 

Second Dose

Primary Series

Three weeks after your first dose

Third Dose

Primary Series

At least four weeks after your second dose

Fourth Dose

Updated Pfizer or Moderna Booster

At least two months after your third dose or last booster

 

Up to date: immediately after you have received the most recent booster dose recommended for you

First Dose

Primary Series

 

Second Dose

Primary Series

Four weeks after your first dose

Third Dose

Primary Series

At least four weeks after your second dose

Fourth Dose

Updated Pfizer or Moderna Booster

At least two months after your third dose or last booster

 

Up to date: immediately after you have received the most recent booster dose recommended for you

First Dose

Primary Series

 

Second Dose

Primary Series

Three weeks after your first dose

Third Dose

Updated Pfizer or Moderna Booster

At least two months after your second dose

 

Up to date: immediately after you have received the most recent booster dose recommended for you

Pfizer or Moderna COVID-19 vaccines are preferred over Johnson & Johnson’s COVID-19 vaccine in most situations, due to the risk of serious adverse events.

First Dose

Primary Series

 

Second Dose

Additional dose of Monovalent Pfizer or Moderna

At least four weeks after your first dose

Third Dose

Updated Pfizer or Moderna Booster

At least two months after your second dose or last booster

 

Up to date: immediately after you have received the most recent booster dose recommended for you


Layers of protection

COVID-19 vaccines and booster doses are important to help prevent COVID-19 hospitalizations and death. However, immunocompromised people may still have a reduced immune response. To stay protected against COVID-19, the Department of Health Services recommends all Wisconsinites continue to practice layered COVID-19 prevention strategies based on their COVID-19 Community Level and individual level of risk. This means it is still important for immunocompromised people to continue to follow current prevention measures (like wearing a mask and physical distancing) even after being up to date on COVID-19 vaccines.

You may also be eligible for Evusheld, a medicine given by a health care provider to help prevent you from getting COVID-19.


Find COVID-19 vaccine or booster doses near you

Visit vaccines.gov, text your zip code to 438829, or dial 211 to find vaccine locations near you. You do not need an ID or insurance to get it.

If possible, bring your white CDC COVID-19 vaccination card or a printed or downloaded summary of your vaccine record.

Find an appointment

211 Wisconsin

Call 211 or 877-947-2211 to get referrals for thousands of services across Wisconsin. For COVID-19 questions, text COVID to 211-211. Language assistance is available.

Resilient Wisconsin

Get help learning how to manage stress and adapt to change with services and support from organizations across the state.

Helpful resources

Find help with housing, income, food, employment, health care, mental health concerns, safety at home, and more—in multiple languages.
Last revised December 23, 2022